Abstract
PurposeInvestigation of the antibacterial action of aqueous extracts of Bidens sulphurea, Bidens pilosa, and Tanacetum vulgare, species of Asteraceae family that are popularly used for the treatment of genito-urinary infection.MethodsThe minimum inhibitory concentration (MIC) and minimal bacterial concentration (MBC) of the extracts against standard strains of Staphylococcus aureus (ATCC25923), Enterococcus faecalis (ATCC29212), Escherichia coli (ATCC25922), and Pseudomonas aeruginosa (ATCC27853) and against bacteria that were isolated from cultures of vaginal secretions and urine from menopausal women with a diagnosis of recurrent urinary tract infections (rUTI) were determined by broth microdilution.ResultsThe MIC values of the three extracts against Gram-positive and Gram-negative standard bacterial strains ranged from 7.81 to 125.00 mg ml-1, and the MBC values ranged from 7.81 to 500.00 mg ml-1. However, B. sulphurea was more efficient. In the urine samples, the three extracts inhibited the growth of coagulase-negative Staphylococcus spp., and the B. pilosa was the most active extract against E. coli compared with the other ones. For the vaginal secretion samples, no significant differences in the inhibition of coagulase-positive Staphylococcus spp. and P. mirabilis were found among the extracts. T. vulgare and B. sulphurea were more effective in inhibiting coagulase-negative Staphylococcus spp. compared with B. pilosa. E. coli was more susceptible to the B. sulphurea extract compared with the B. pilosa and T. vulgare extracts.ConclusionThe present results suggested the potential medicinal use of Asteraceae species, especially B. sulphurea, as therapeutic agents against rUTI-related bacteria.
Highlights
Urinary tract infections (UTIs) are the most common bacterial infections in women, and their incidence rises in the postmenopausal period mainly because of lower estrogen production [1]
The three extracts inhibited the growth of coagulase-negative Staphylococcus spp., and the B. pilosa was the most active extract against E. coli compared with the other ones
The present results suggested the potential medicinal use of Asteraceae species, especially B. sulphurea, as therapeutic agents against recurrent urinary tract infections (rUTIs)-related bacteria
Summary
Urinary tract infections (UTIs) are the most common bacterial infections in women, and their incidence rises in the postmenopausal period mainly because of lower estrogen production [1]. Among the types of UTIs, recurrent urinary tract infections (rUTIs) are one of the most common problems in urology. Recent studies indicated that rUTIs should be considered as different from primary UTIs [2]. Among the main causative microorganisms of rUTIs are aerobic Gram-negative bacteria that are present in the intestinal microbiota, including members of the Enterobacteriaceae family, such as the genera Escherichia, Enterobacter, Klebsiella, Serratia, Proteus, Salmonella, and Shigella [3]. In community-acquired UTIs, Escherichia coli accounts for approximately 85% of cases. In chronic infections and hospital- or structure-related anomalies of the urinary tract, there is a more equitable distribution of different enterobacteria, with a higher prevalence of UTIs that are caused by Proteus spp., Klebsiella spp., Enterobacter spp., Pseudomonas spp., and Gram-positive Staphylococcus saprophyticus and Enterococcus spp. In chronic infections and hospital- or structure-related anomalies of the urinary tract, there is a more equitable distribution of different enterobacteria, with a higher prevalence of UTIs that are caused by Proteus spp., Klebsiella spp., Enterobacter spp., Pseudomonas spp., and Gram-positive Staphylococcus saprophyticus and Enterococcus spp. [4]
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