Abstract
Recently, among hospital strains of microorganisms, an increase in the number of antiseptic-resistant strains of opportunistic pathogens has been registered, which significantly affects the effectiveness of these drugs. It is important to study their antimicrobial efficacy to justify rational use. The aim is to conduct a comparative study of the antimicrobial efficacy of antiseptics of decamethoxine, chlorhexidine, polyhexanide. During study we examined the antimicrobial activity against 186 clinical strains of microorganisms (Acinetobacter baumannii, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus spp., Enterobacter spp.) isolated from patients with infectious complications in the postoperative period. The minimum inhibitory (MIC) and bactericidal concentrations (MBC) of 0.02 % and 0.1 % decamethoxine, 0.05 % chlorhexidine bigluconate, 0.1 % polyhexanide were determined; antimicrobial efficacy of drugs was evaluated by the index of antiseptic activity by conventional methods. The study found high antimicrobial properties of decamethoxine, chlorhexidine, which had a high bactericidal effect on clinical strains of S. aureus, Enterococcus spp., Enterobacter spp. Proved the benefits of antimicrobial activity of the drug based on decamethoxine (p<0.001). The polyhexanide has pronounced antimicrobial properties against A. baumannii, bacteria of the family Enterobactericae, P. aeruginosa. Thus, the leading gram-positive (Staphylococcus aureus, enterococci) and gram-negative pathogens (enterobacteria, acinetobacteria, pseudomonads) are sensitive to polyhexanide, chlorhexidine and the domestic drug decamethoxin, with a probable advantage of the antimicrobial properties of the latter over all gram-positive and most gram-negative microorganisms.
Highlights
Prevention of postoperative infectious complications has been and remains one of the most pressing problems of surgery, both in our country and abroad [20]
Among the known list of antiseptic drugs registered in Ukraine, 0.02 % decamethoxine and 0.05 % chlorhexidine bigliuconate are actively used in the prevention and treatment of infectious complications of the respiratory system [3]
On clinical strains of opportunistic pathogens isolated from patients with infectious complications in the postoperative period, who were treated in burns for severe burns, were studied antimicrobial efficacy of antiseptics based on polyhexanide, decamethoxine, chlorhexidine
Summary
Prevention of postoperative infectious complications has been and remains one of the most pressing problems of surgery, both in our country and abroad [20]. Infectious complications in the postoperative patient in most cases occur due to opportunistic pathogens that have become resistant to a wide range of antimicrobials [20]. The selective action of antiseptic drugs leads to the elimination of sensitive cells of the microbial population and the spread of antiseptic-resistant strains [13, 18]. In such conditions, the use of antiseptics with a wide range of antimicrobial action is considered a priority. Among the known list of antiseptic drugs registered in Ukraine, 0.02 % decamethoxine and 0.05 % chlorhexidine bigliuconate are actively used in the prevention and treatment of infectious complications of the respiratory system [3]. Polyhexanide is known among the arsenal of modern antiseptics [12]
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