Anti-Inflammatory, Analgesic, and Antipyretic Activities of the Ethanol Extract of Piper interruptum Opiz. and Piper chaba Linn.

Seewaboon Sireeratawong,Nusiri Lerdvuthisopon,Arunporn Itharat,Kanjana Jaijoy,Pritsana Piyabhan,Supot Boonraeng,Parirat Khonsung

doi:10.5402/2012/480265

Seewaboon Sireeratawong, Nusiri Lerdvuthisopon + Show 5 more

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https://doi.org/10.5402/2012/480265

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Abstract

Piper interruptum Opiz. and Piper chaba Linn. are herbaceous plants in the Piperaceae family. The ethanol extract of P. interruptum and P. chaba inhibited ethyl phenylpropiolate-induced ear edema and carrageenan-induced hind paw edema in rats. Both extracts reduced transudative and granuloma weights as well as body weight gain and thymus weight of the chronic inflammatory model using cotton pellet-induced granuloma formation in rats. Moreover, both extracts exhibited analgesic activity on both early phase and late phase of formalin test in mice and also showed antipyretic activity on yeast-induced hyperthermia in rats.

Highlights

The Piperaceae is a huge family of plants, which has been extensively used for traditional medicine
Results of the present study reveal that ethanolic extracts of Piper interruptum Opiz. and Piper chaba Linn. possesses antiinflammatory, analgesic, and antipyretic activities in animal models
The carrageenan-induced paw edema is considered as a model of the acute phase of inflammation which is widely used for discovery and investigation of anti-inflammatory drug [15]

Summary

Introduction

The Piperaceae is a huge family of plants, which has been extensively used for traditional medicine. The stem has long been used as carminative, antiflatulent, and tonic element [1]. The ethanol extract of stem showed larvicidal effect [2] and the methanol extract exhibited inhibitory activity on acetylcholinesterase enzyme [3]. In Thai traditional systems of medicine, the dried mature unripe fruits of this plant find wide application as carminative, element tonic, antidiarrheal, expectorant and oxytocic for postlabor [4]. The fruit extract of P. chaba has been shown to exhibit various activities including antiinflammation [5,6,7], hepatoprotection [8], cytotoxicity and antitumor [9], chemoprevention [10], antiangiogenesis [11], immunomodulation [12], and adipogenesis [13]

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