Abstract
Benincasa hispida (Ash gourd, family: Cucurbitaceae) is well known for its medicinal property. In the Ayurvedic system, it is used as a rejuvenating agent and in the treatment of nervous disorders. Methanolic and petroleum fruit extracts was subjected to evaluation of phytochemicals and acute oral toxicity study. Further, Anti-inflammatory activity was performed using human red blood cell (HRBC) membrane stabilization assay and carrageenan induced paw edema in rat. Oral administration of methanolic extract of concentration (350 mg/kg) significantly reduced the paw edema (P < 0.05) in a dose dependent manner as compared to carrageenan induced rats.
Highlights
Nature has provided many compounds of significant medicinal application that play an important & often dominant role in the maintenance of human health
The concentration of methanolic and petroleum fruit extract of Benincasa hispida up to 2000 mg/kg body weight did not show any sign of toxicity and it was considered to be safe
The activated neutrophils released enzymes can cause the tissue injury which may damage the macromolecules and lipid peroxidation of membranes that are assumed to be responsible for globally prevalence disease, such as atherosclerosis, rheumatoid arthritis and asthma
Summary
Nature has provided many compounds of significant medicinal application that play an important & often dominant role in the maintenance of human health. Inflammation is a complex part of the body’s immune response to a native substance which produces excessive amount of free radical causing lipid peroxidation resulting in membrane destruction followed by production of mediator and chemotactic factor [4]. It is correlated with the different disease such as rheumatism, encephalitis, fibrosis, cancer [5], heart problem etc. Herbal extracts and treatments are found to be safer alternatives so extensive research can be done for potential anti inflammatory activity
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