In vitro and In vivo anti-inflammatory activity of leaves of Symplocos cochinchnensis (Lour) Moore ssp laurina

Rajendran Vadivu,K.S Lakshmi

doi:10.3329/bjp.v3i2.956

Abstract

The anti-inflammatory activities of different extracts of leaves Symplocos cochinchinensis Lour ssp laurina (Symplococaceae) were investigated for i n vitro anti-inflammatory activity by human red blood cell membrane stabilization method. The methanol extract showed effective in vitro anti-inflammatory activity was screened for in vivo antiinflammatory activity by carrageenan-induced paw edema in rat model. The potency of the extracts was compared with standard diclofenac (50 mg/kg). The methanol extract showed significant membrane stabilizing action on human red blood cell membrane and reduction of edema in carrageenan induced rat paw edema model.

Highlights

Symplocos cochinchinensis Lour ssp laurina (Symplococaceae) otherwise known as kablivetti or Lodh tree is widely distributed in tropical, subtropical areas in Asia, Oceania and America
It is widely used in the treatment of various disorders like leprosy, tumors, diarrhea, dysentery, menorrhagia, inflammation and uterine disorders (Ali et al, 1990)
The inflammatory response involves a complex array of enzyme activation, mediator release, fluid extravasations, cell migration, tissue breakdown and repair (Vane et al, 1995) which are aimed at host defense and usually activated in most disease condition

Summary

July 2008 28 July 2008 1 August 2008

Cite this article: Vadivu R, Lakshmi KS. In vitro and In vivo anti-inflammatory activity of leaves of Symplocos cochinchinensis (Lour) Moore ssp laurina. The anti-inflammatory activities of different extracts of leaves Symplocos cochinchinensis Lour ssp laurina (Symplococaceae) were investigated for in vitro anti-inflammatory activity by human red blood cell membrane stabilization method. The methanol extract showed effective in vitro anti-inflammatory activity was screened for in vivo anti-inflammatory activity by carrageenan-induced paw edema in rat model. The potency of the extracts was compared with standard diclofenac (50 mg/kg). The methanol extract showed significant membrane stabilizing action on human red blood cell membrane and reduction of edema in carrageenan induced rat paw edema model

Introduction

Materials and Methods

Results and Discussion