Antihyperlipidemia activity of ethanol extract the stem bark of Flacourtia rukam on propylthiouracil-induced albino rats, Rattus noverticus (Wistar strain)

Abstract

Flacourtia rukam belongs to one of the traditional medicinal plants used by the people, especially in South Sumatra for the treatment of hypertension. One of the triggers for hypertension is high levels of cholesterol in the blood. The in vivo research of the anti-hyperlipidemia activity of ethanol extract the stem bark of F. rukam on Propylthiouracil-induced albino rats Rattus noverticus (Wistar Strain) has been done. The animal test was separated into 6 groups i.e. normal group, negative, positive (simvastatin), and 3 treatment groups with a variation extract dose of 100, 200, and 400 mg/kg BW. The measurement of total cholesterol, triglyceride, LDL and HDL levels using the photometric enzymatic method. The result shows that ethanol extract of F. rukam gives the highest anti hyperlipidemia activity at 400 mg/kg BW with decreased total cholesterol percentage of 56.28%, triglycerides 57.34 %, LDL 54.29%, and increased HDL 58.77%. Statistical analysis shows that the treatment groups I, II, and III can reduce the level of total cholesterol, triglycerides, and higher-level LDL. The effective dose (ED50) is 327.83 mg/kg BW. Based on this result, the traditional plant can be used in hyperlipidemia treatment.