Abstract
Context: Syzygium cumini commonly known as jamun, a tree grown throughout India is used in traditional medication for the treatment of different diseases and ailments of human beings. Objective: In this study, the seed extract of Syzygium cumini was evaluated for anti-hyperlipidemic activity in alloxan induced diabetic mice. Materials and methods: LD50 and acute toxicity studies of Syzygium cumini (SC) were done. Hyperglycemia was induced in mice by alloxan. Three days after alloxan induction, the hyperglycemic mice were treated with Syzygium cumini orally at the dose of 150 and 250 mg/kg body weight daily for 21 days. After 21days of treatment, the animals were sacrificed and serum glucose and lipid profiles were estimated in the serum. Results: The LD50 was found to be 1000 mg/kg; 150 and 250 mg/kg doses were selected as no toxic symptoms were observed at both doses. SC significant (p<0.05) reduced serum glucose level, CH, TG-C, LDL-C, VLDL-C and increased HDL-C, body weight and liver, kidney weight. Conclusion: The above results prove potential of hypoglycemic and anti-hyperlipidemic activity Syzygium cumini.
Highlights
Diabetes mellitus (DM) is a chronic metabolic disorder that affects a significant portion of the population worldwide [1]
Non-insulin dependent Diabetes mellitus (NIDDM) is a multifactorial disease, which is characterised by hyperglycemia and lipoprotein abnormalities [4]
NIDDM has been associated with an increased risk for developing premature atherosclerosis due to an increase in triglycerides (TG) and low-density lipoproteins (LDL), and decrease in high-density lipoprotein levels (HDL) [5]
Summary
Diabetes mellitus (DM) is a chronic metabolic disorder that affects a significant portion of the population worldwide [1]. DM is a group of metabolic diseases characterized by hyperglycemia, hypertriglyceridemic and hypercholesterolemia, resulting from defects in insulin secretion, its action or both [2] Both type 1 and type 2 diabetes are known to be multifactorial diseases caused by a combination of genetic (inheritance) and environmental (diet and lifestyle) factors [3]. Non-insulin dependent Diabetes mellitus (NIDDM) is a multifactorial disease, which is characterised by hyperglycemia and lipoprotein abnormalities [4]. These traits are hypothesised to damage cell membranes, which results in excess generation of reactive oxygen species. Two groups of oral hypoglycemic drugs, sulphonylurea and biguanides, have been used in the treatment of DM They act by lowering blood glucose thereby delaying or preventing the onset of diabetic complications [6]. The present study was taken up to explore antidiabetic potential of Syzygium cumini seeds and to reduce the risk of late complications and negative outcomes of diabetes mellitus which requires to control blood glucose level and to control lipid profile
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