Abstract
Hyperlipidemia is the greatest risk factors that precipitate coronary heart disease. Medicinal may confer hypolipidemic effects in order to compliment the cardiovascular diseases treatment regimen. The aim of this study was to investigate hypolipidemic effect of cinnamon bark ethanolic extract in Triton X-100 induced hyperlipidemic in rats. Twenty five adult male albino rats (150-250 g) were randomly divided into five groups: group A stand as negative control, group B stand as positive control, groups C and D received 250 and 500 mg/kg cinnamon extract respectively and group E received atorvastatin 10 mg/kg after of induction of hyperlipidemia by Triton X-100 for seven days. The results was showed a significant (p<0.05) hypolipidemic effect on cholesterol and triglycerides of cinnamon extract in groups administered 250 and 500 mg/kg compared with the negative and positive control group. Also the hepatic histopathological study was showed that the cinnamon ethanol extract has preventive effect from liver fatty infiltration and granular degeneration.
Highlights
Blood lipids and lipoproteins abnormalities are preceding risk factor for cardiovascular diseases; hyperlipidemia contributes significantly within the prevalence and severity of atherosclerosis and coronary arteries diseases [1,2]
In this study Triton x-100 was chosen for the induction of hyperlipidemia which as an acute model for induction of hyperlipidemia in rats
Triton X-100 reported to be block the clearance of TG-rich lipoproteins and produces acute hyperlipidemia in animal models and it enhance serum TG and cholesterol levels as an increase of Low Density Lipoprotein (LDL) secretion by the liver, followed by reduction of LDL catabolism [16]
Summary
Blood lipids and lipoproteins abnormalities are preceding risk factor for cardiovascular diseases; hyperlipidemia contributes significantly within the prevalence and severity of atherosclerosis and coronary arteries diseases [1,2]. Cinnamomum zeylanicum is small ever green tree native to India and Sri Lanka, early decades cinnamon bark available only as a wild plant but entire barks obtained from cultivated plants [8]. It was used as antioxidant [9], anti-inflammatory [10], antidiabetic [11], anti-cancer [12] and antimicrobial [13], and traditionally it was used mainly in aroma and essence industry due to its fragrance, as a spice in food stuffs and drinks [14] as well. Cinnamon bark major active constituents are volatile oil (cinnamaldehyde, eugenol, linalool, safrole, pinene, phyllandrene, cymene and cineol), tannins constituting polymeric 5,7,3,4-tetrahydroxy -tetrahydroxy flavan-3-4-diol units, catechins, proanthocyanidins and resins [15]
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