Abstract
Genetic expression of associated antigen heterogeneity in cancer partially explains the apparent inconsistency in relating CIC concentration to clinical status (Salinas et al., 1983). We have assessed CIC and antibody levels (Ab) in the sera of 43 sarcoma patients who were grouped according to tumor burden. Nine of 22 Gp I pts with no evidence of disease showed increased CIC with a mean of 71 μg AHG/ml (p ≤ 0.01). All Gp II pts with relatively small tumor burden had a mean CIC of 26 μg AHG/ml, while the 13 Gp III pts with advanced metastatic disease showed a significantly increased mean of 44 μg AHG/ml (p>0.01). Although Ab levels remained elevated for all tumor groups, their mean values demonstrated an inverse relationship to CIC concentrations. Selected follow-up pts with disease regression showed concomitant increased CIC values, while those with disease progression showed decreased CIC levels. CIC-derived SAA demonstrated an apparent single molecular weight of 26 Kilodalton (Kd) despite isoelectic points at 5.6 and 6.4. Upon SAA reaction with autologous and allogenic patientS' sera, a reduction of CIC size and concentration resulted for all combinations, except for Gp II autologous combination.
Published Version
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