Abstract
Abstract: The antigen receptors of T lymphocytes are investigated in two experimental systems: a) anti-idiotypic antisera raised against isolated humoral antibodies are used for the idiotypic analysis of T-cell receptors at the level of T-cell function; b) antigen-binding receptor material is isolated from T and B lymphocytes and studied at the molecular level. Our investigations concern: a) the cellular location or origin of the receptors, b) their specificity for antigen, c) the serological characteristics of receptors as studied by antisera against H-2 antigens and constant and variable regions of immunoglobulin light and heavy chains, and d) the molecular properties of receptors. The complete structure of the antigen receptor of T lymphocytes remains unknown. It is shown, however, that the T-cell receptor carries the variable region of immunoglobulin heavy chains but probably no other part of conventional heavy or light chains.
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