Abstract
In this paper we describe a method for stimulating T-lymphocyte proliferation using antigen bound to spleen cells. With this form of antigen presentation, syngeneic spleen cells were found to present antigen better to peritoneal exudate T-lymphocyte-enriched cells (PETLES) than semisyngeneic spleen cells, which in turn could present antigen better than allogeneic spleen cells. Spleen cell mixing experiments demonstrated that these genetic restrictions were not the result of nonspecific suppression by the ongoing mixed lymphocyte reactions (MLR). Furthermore, incompatibility at the Mls locus generated a strong MLR but failed to prevent antigen presentation if the spleen cells and PETLES were H-2 compatible. Through the use of H-2 congenic-resistant lines and their recombinant strains, it was possible to map at least one gene controlling the successful presentation of the antigen, DNP 6 -ovalbumin, to the I-A subregion of the major histocompatibility complex (MHC) .
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