Abstract
The acetone extract of the bark ofMagnolia obovata Thunb. had potent antifungal activity against plant pathogenic and wood destroying fungi. The active principles were isolated and identified to be eudesmols (I), magnolol (II) and honokiol (III). Eudesmols, which are main components of the volatile bark oil, showed strong antifungal activity against all of the fungi tested, especially basidiomycetes. It completely inhibited the growths ofCoriolus versicolor, Lepista sordida, Pycnoporus coccineus, Rhizoctonia solani, Serpula lacrymans andTyphula ishikariensis at a concentration of 500 μg mL−1. Two biphenyl type neolignans, magnolol and honokiol, also exhibited potent antifungal activity against these fungi except againstC. versicolor andL. sordida. They completely depressed the growths ofS. lacrymans andT. ishikariensis at the same concentration.
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