Abstract
Objective: Garcinia mangostana is a plant that can be used as a traditional medicine to treat various infectious diseases for the treatment of diarrhea, skin infection, and chronic wounds. The activity as antifungal and antibacterial of juice and ethanolic extract from G. mangostana leaves were investigated.
 Methods: Juice and ethanolic extract were concentrated using a rotary evaporator to get concentrated extract with rendemen 2.571 and 5.647% (w/w). Juice and ethanolic extract dilution method were employed to evaluate the antifungal activity against Saccharomyces cerevisiae. Ethanolic extract dilution method was used to assess the antibacterial activity against Bacillus subtilis and Escherichia coli.
 Results: The results of this research showed that juice and ethanolic extract were effective against S. cerevisiae, and the minimum inhibitory concentration was 1000, and 500 mg/mL. Antibacterial activity of the G. mangostana leaves ethanolic extract showed that the action was potential with the inhibition zone in B. subtilis and E. coli. 
 Conclusions: The conclusion of this study is that juice and ethanolic extract of G. mangostana leaves have possible antifungal and antibacterial activity.
Highlights
Mangosteen (Garcinia mangostana) is one of the primary commodities of Indonesian export, known as the queen of tropical fruits
Preparation ethanolic extract The leaves of G. mangostana were collected, dried, and pulverized using a mechanical grinder. 500 g of powder were extracted by maceration method with solvent water: ethanol 50% (1:5) during 24 h and re-maceration with solvent water: ethanol 50% (1:4)
This study was designed to assess the antifungal activities from juice and ethanolic extract and to determine the antibacterial activities of ethanolic extract of G. mangostana
Summary
Mangosteen (Garcinia mangostana) is one of the primary commodities of Indonesian export, known as the queen of tropical fruits. Several studies have shown that obtained xanthones from G. mangostana have remarkable biological activities such as antioxidant, antitumor, anti-inflammatory, antiallergy, antibacterial, antifungal, and antiviral activities [2,3]. The twig extract of G. mangostana was the most useful sample against platelet aggregation caused by arachidonic acid [4], and several studies had been designed to examine the anticancer activities, hepatocellular carcinoma human leukemia of xanthones from mangosteen fruit pericarp [5]. The leaves of G. mangostana are proven to have high phenolic compounds and have the potential as antibacterial and antitumor activity [7]. Juice of leaves of G. mangostana was shown to have free radical scavenging activity against α,α-diphenylβ-picrylhydrazyl (DPPH) radicals with IC50 19 ppm [8]. The use of leaves of G. mangostana as traditional medicine is by making juice
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