Antifungal Activities and Characterization of Some New Environmentally Safe Cu (II) Surfactants Substituted 2-Amino-6-Methyl Benzothiazole

Arun Kumar Sharma,Antima Gangwal,Rashmi Sharma

doi:10.2174/1874844901805010001

Abstract

Background:Biologically potent compounds are one of the most important classes of materials for the upcoming generations.Objectives:Increasing number of microbial infectious diseases and resistant pathogens create a demand and urgency to develop novel, potent, safe and improved variety of antimicrobial agents.Methods:The copper surfactants substituted 2-amino-6-methyl benzothiazole were synthesized. The synthesized complexes have been characterized by IR, NMR, ESR spectroscopic methods. The antifungal activities have been evaluated by testing againstAlternaria alternatefungi. All complexes showed good antifungal activity because chelation increases the anti-microbial potency.Result:The studies suggest that the copper (II) ions in soaps may be responsible for the enhancement of the activity against fungi. The evaluation of anti -fungal studies further revealed that fungitoxicity of the complexes also depends on the nature of metal ions. The chelation reduces the polarity of central metal ion mainly because of partial attaining of its positive charge with the donor groups and possible π- electron delocalization over the whole chelate ring. Such chelation increases the lipophilic character of the central atom, which subsequently favors its permeation through the lipoid layer of the cell membrane. Their efficiency increases with their concentration.

Highlights

Colloidal surfactants have become one of the most important requirements in day to day life, and have great importance in modern engineering and pharmacological fields
The detailed infrared spectral investigation reveals that there are marked differences between the spectra of pure copper soaps and pure ligand than those of the corresponding complexes (Table 2) The absorption bands observed in the region 2960-2950 cm-1 and 2900-2950 cm-1 respectively were assigned to the antisymmetric stretching for methyl group of the soap segment present in the complex
The organic compounds containing amino group play an important role in biology, as it constitutes the repeating unit of the polypeptide macromolecules. These results show that the Cu (II) soap-complexes of ligands are much more toxic than the ligands themselves [29]

Summary

Introduction

Colloidal surfactants have become one of the most important requirements in day to day life, and have great importance in modern engineering and pharmacological fields. Many copper thiosemicarbazone complexes have been found to have significant anti-tubercular, fungicidal and antitumor activities [1, 2]. The use of copper linoleate as heavy duty wood preservative and many other biological activities of copper metal-containing surfactants have been studied [3, 4]. The deeper understanding of the role of metal ion in bio-system has led to the awareness that metal complexing is useful in the treatment of bacterial, fungicidal and viral diseases [5, 6].Many copper compounds are employed as pesticides either alone (as Cu (I) oxide and Cu (II) sulfate) or in mixtures [7]. Potent compounds are one of the most important classes of materials for the upcoming generations

Objectives

Results

Conclusion