Abstract
The purpose of the present study was to determine the anti-fatigue and anti-hypoxia effects of soy isoflavones. Soy isoflavones were administered at doses of 200, 400, 600 mg/kg and anti-fatigue effects were evaluated using rotarod and forced swimming test, along with the determination of fatigue-related some blood biochemical parameters. Meanwhile, anti-hypoxia effects were evaluated using normobaric hypoxia and sodium nitrite toxicosis test. The results showed that soy isoflavones could evidently extend riding and exhaustive swimming times, decreasing blood lactate and serum urea nitrogen contents, which indicated that soy isoflavones had anti-fatigue effects. Soy isoflavones could evidently extend survival times under normobaric hypoxia and sodium nitrite toxicosis conditions, which indicated that soy isoflavones had anti-hypoxia effects.
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