Abstract
The present study was designed to investigate the anti-fatigue effects of polysaccharides from A. sinensis (APS). The mice were divided into 4 groups: normal control, low, middle, and high-dose APS treated group. Normal control group was treated with distilled water, while APS treated groups received different doses of APS by oral gavage once daily for 28 day. The anti-fatigue effects were evaluated using the forced swimming test, along with the determination of exhaustive swimming times and fatigue related biochemical parameters such as blood lactic acid, serum urea nitrogen, liver glycogen, muscle glycogen, and serum creatine kinase. The data showed that APS could prolong the exhaustive swimming times in mice, reduce blood lactic acid production or promote blood lactic acid elimination, as well as decrease the serum urea nitrogen contents, and increase contents of liver and muscle glycogen. Therefore, APS has anti-fatigue effects.
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