Abstract
The existing description is a study of the antiepileptic effect of Datura inoxia as a recognized herb that is used in Ayurveda for asthma, rheumatism, tumors, cough, fever, antimicrobials and epilepsy. Toxicity studies were carried out for standardizing a dose of aqueous extract of D. inoxia, maximal electroshock (MES) and isoniazid (INH) induced seizures. The Albino mice model were used for screening the antiepileptic activity. As per OECD guideline no. 423, up to 2000 mg/kg body weight of recommended dose of extract were found toxic. Animals were treated with aqueous extract of 200, 400 and 600 mg/kg body weight. Phenytoin was used as reference anticonvulsant drugs for comparison. The investigation stated the significant interruption in the INH-induced clonic seizure and in MES model, reduction in the period of hind leg extensor phase. In MES model, D. inoxia exhibited a significantly decrease in the duration of hindlimb extension with 400 and 600 mg/kg dose, respectively. Comparable results were obtained in INH model by delayed onset of a clonic seizure. Aqueous extract of D. inoxia exhibited antiepileptic action against MES and INH-induced epilepsy in animal models.
Published Version
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