Antidiabetic potential of sea fish mass by inhibiting di-peptidyl peptidase-IV and augmenting glucagon-like peptide-1 on high lipid diet and streptozotocin induced diabetic rats

Abstract

Many studies have revealed that sea fish is a rich source of nutrients, especially protein and there peptide. In this study, antidiabetic activity of the fish masses of three sea-fishes ‘volavetki’ (Panna microdon, Bleeker 1849), ‘ruli’ (Coilia dussumieri, Valenciennes 1848), ‘tapra’(Opisthopterus tardoore, Cuvier 1829) and one fresh-water fish ‘murola’(Amblypharyngodon mola, Hamilton 1822),evaluated high lipid diet (HLD) and STZ induced Type 2 Diabetic Mellitus (T2DM) rats. Supplementation of sea-fish masses and antidiabetic effect was monitored by fasting plasma blood glucose and HbA1c. Also, insulin, c-peptide, glucagon-like peptide-1, dipeptidyl peptidase-IV, glucokinase, glucose-6 phosphatase, superoxide dismutase, glutathione peroxidase, catalase, plasma total cholesterol, low density lipoprotein, triglycerides, high density lipoprotein and histopathology of free radical activity of pancreatic tissues were evaluated. Out of four fish masses, volavetki sea fish masses oral supplementation resulted in significant reduction of plasma blood glucose, HbA1c of T2DM rat. All other parameters in T2DM rats were returned to near normal by treatment of volavetki sea fish mass. Our findings strongly indicated that volavetki sea fish highly showed antidiabetic activity.