Abstract
AbstractAll around the world, patients with diabetes and the prevalence of its disease are currently growing. Due to these side effects of oral hypoglycemic agents and oxidative stress in complicating diabetes, there is growing interest in drugs, which possess dual function as both type II diabetes mellitus treatment and oxidative stress treatment. The objective of this research is to search effective antidiabetes and antioxidant bioactive compounds from the Myanmar medicinal plantClausena excavata. The root part ofC. excavatawas successfully extracted with 95% ethanol and followed by column chromatographic separation technique. The structure of isolated pure compounds was elucidated by using methods of spectroscopic such as UV-Vis, IR, NMR and HRFABMS spectrometry. The α-glucosidase inhibition assay was performed against baker’s yeast and rat intestine (sucrose and maltase) α-glucosidases. The activity of isolated compounds’ antioxidant was measured by using DPPH assay. Among the tested enzymes, the two isolated compounds, which were dentatin (1) and heptaphylline (2), exhibited highest inhibitory on maltase enzymes with IC50values 6.75 and 11.46 μM; as positive control, acarbose (IC50, 2.35 μM) was utilized. Moreover, scavenging activity was found to be present upon seeing the result of antioxidant activity investigation of (1) and (2) (IC50values 2.66 and 1.55 mM), where ascorbic acid (IC500.012 mM) was used as standard. Both compounds showed their antidiabetic and antioxidant activity with different fashion, especially exhibited strongest activity against on maltase α-glucosidase.
Highlights
Diabetes is a chronic metabolic disorder that could be serious and lethal
Due to 7-oxygenated coumarin, absorption maxima were exhibited by the spectrum of UV at 330 and 272 nm
In searching antidiabetic and antioxidant agents from Myanmar medicinal plant C. eacavata root ethanolic extract lead to the isolation of two known bioactive compounds namely dentatin (1) and heptaphylline (2)
Summary
Diabetes is a chronic metabolic disorder that could be serious and lethal. It is characterized by relative or absolute insufficiencies which occurs either when the body cannot effectively use the insulin (a hormone that regulates blood glucose) it produces, or when the pancreas does not produce adequate insulin [1]. Diabetes is lethal but it is the major cause of blindness, heart attacks, kidney failure, strokes, gangrene, and neuropathy especially for adults [3]. There were 422 million diabetic adults (or about 8.5% of the world’s population) in 2014. The number increased highly compared to the year of 1980 with 108 million of diabetic adults (4.7% of the world’s population) [4]
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