Anticoagulant and antioxidant properties of hemodialysis membranes modified by hydrogels incorporating carbon dots

Abstract

Hemodialysis membranes play an important role in the treatment of renal failure, but their anticoagulant and antioxidant properties need to be improved to prevent membrane fouling and oxidative stress in dialysis. To these ends, a heparinoid gel incorporating carbon dots (CDs) was applied to modify polyethersulfone hemodialysis membranes. The CDs were mixed with ammonium persulfate, Sodium p-styrene sulfonate, and N, N - Methylenebisacrylamide monomers, and modified to surfaces of hemodialysis membranes through the in-situ polymerization of these monomers. As prepared hybrid hydrogel featured a high free radical scavenging rate and anticoagulant time for the hemodialysis membrane. The scavenging rates of the modified membrane for 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate (ABTS+) free radicals are as high as 74.01% and 97.78%. The activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) of the dialysis membrane are 600 s,283 s and 348 s, respectively.