Роль форменных элементов крови в формировании гемокоагуляционных сдвигов при гипертонической болезни

Abstract

Aim. To study the role of different blood cells in the development of coagulation potential in healthy women and patients with essential hypertension (EH). Methods. The study included 102 women. The control group consisted of 30 relatively healthy women. Patients with EH were divided into 2 subgroups: the first subgroup (EH-1) included 37 women with stage II arterial hypertension, the second subgroup (EH-2) — 35 women with stage II EH who received 3-4 courses of kinesitherapy for 2-3 years on a regular basis. The following values were determined: platelet count, activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen concentration, and spatial fibrin clot growth, including the delay time of clot lengthening, initial and steady growth rate, and clot density and size. The role of different blood cells in the development of coagulation potential was evaluated in healthy and EH women using the correlation analysis. Results. All women had increased numbers of lymphocytes and eosinophils; showed a predisposition to thrombosis as was evident from thrombodynamic properties of the clot; and increased formation rate and size of the fibrin clot. These changes were less pronounced in the EH-2 group. In healthy women, a direct correlation was observed between the number of monocytes, APTT and the thrombin time. and a negative correlation — between the number of lymphocytes and APTT. In this group, the number of eosinophils positively correlated with the prothrombin time and the clot density. In the EH-1 group, the number of neutrophils inversely correlated with the rate of clot formation; the number of monocytes positively correlated with the clot formation rate and size; and the number of basophils positively correlated with the thrombin time. In EH-2 patients receiving kinesitherapy, the number of red cells inversely correlated with APTT; the number of platelets positively correlated with the thrombin time, the clot formation rate and size; and the total number of leukocytes positively correlated with the prothrombin time and the clot formation rate. The neutrophil count positively correlated with the prothrombin time and negatively — with the rate of clot formation. The number of lymphocytes and eosinophils negatively correlated with the rate of clot formation, and the number of basophils — with the fibrinogen level and the rate of clot emergence. Conclusion. Platelets and leukocyte populations play the main role in the formation of coagulation potential in healthy women and patients with EH. The beneficial effect of kinesitherapy is discussed.