Abstract
Problem statement: Myocardial infarction is the combined result of environmental and personal factors. Data concerning the relation between anti-Phospholipid (aPL) antibodies and myocardial infarction in subjects without evidence of overt autoimmune disease are conflicting. Anticardiolipin antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of Anticardiolipin antibody in Acute Myocardial Infarction (AMI) might shed light on etiologic mechanisms in the pathogenesis of acute coronary syndromes. The purpose of the present study was to determine association of plasma aPL antibodies, namely, anti-Cardiolipin (aCL) antibodies, with AMI. Approach: This study recruited 45 patients with the diagnosis of AMI according to WHO criteria in their first 24 h of admission. Thirty six matched individuals were studied as the control group with normal coronary artery angiography. Samples were tested for IgG-class antibodies to cardiolipin by an ELISA and the results were compared. Results: There were not significant differences between plasma level of aCLAs IgG in the patients with AMI on admission ant the control group. Also aCLAs IgG was not correlated with hypertension, diabetes mellitus, hyperlipidemia, sex, age and smoking. Conclusion: Our findings suggest that aCLAs IgG are not indicative of hypercoagulable state in patients with AMI.
Highlights
Myocardial Infarction (MI) is the combined result of environmental factors and Personal predispositions (Zimmerman et al, 1995)
Definitions: Acute Myocardial Infarction (AMI) was defined as chest pain lasting more than 30 minutes accompanied by ischemic electrocardiographic changes and was confirmed by the presence of total Creatinine Phosphokinase (CPK) or MB fraction levels of more than twice the upper normal limit (Antman et al, 2008)
There were no significant differences between the two groups regarding the following variables: age, sex, HTN, Diabetes Mellitus (DM), Low Density Lipoprotein Cholesterol (LDL), High Density Lipoprotein (HDL), total cholesterol and TG
Summary
Myocardial Infarction (MI) is the combined result of environmental factors and Personal predispositions (Zimmerman et al, 1995). Prothrombotic factors may play a more important role in these patients. Various prothrombotic factors and markers of endothelial damage have been associated with an increased risk of myocardial infarction e.g., fibrinogen (Thompson et al, 1995). In addition to mentioned factors autoantibodies may play a more important role in these patients. Various autoantibodies have been associated with an increased risk of myocardial infarction e.g., antiphosphospholipid antibodies (Hughes, 2010). Antibodies binding to anionic phospholipids, such as cardiolipin, are associated with a clinical syndrome characterized in particular by venous and arterial thrombosis, recurrent abortion and thrombocytopenia
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