Abstract
Problem statement: Ischemic cardiac manifestations have been reported in a various percentage of patients with anti-phospholipid antib odies. Data concerning the relation between anti- Phospholipid (aPL) antibodies and myocardial infarc tion in subjects without evidence of overt autoimmune disease are conflicting. Anti-beta2 glyc oprotein-I (anti-beta2-GPI) antibody is detected in various diseases like rheumatoid arthritis, systemi c lupus erythematosus and anti-phospholipid antibody syndrome. The study of anti-beta2-GPI anti body in Acute Myocardial Infarction (AMI) might shed light on etiologic mechanisms in the pat hogenesis of acute coronary syndromes. The purpose of the present study was to determine assoc iation of plasma aPL antibodies, namely, anti- beta2-GPI antibodies, with AMI. This study was desi gned to investigate whether prevalence of anti- beta2-GPI antibodies, in patients who had acute myo cardial infarction and to analyze their relationshi p with traditional cardiovascular risk factors. Approach: We investigated the prevalence of anti-beta2- GPI IgG in a well characterized group of patients w ith AMI as a case group. Sera from 74 patients with AMI and from 76 healthy subjects, matched for age and sex as a control group. Using ELISA to evaluate the presence of IgG isotype of anti-beta2- GPI autoantibodies in their sera. Results: The prevalence of anti-beta2-GPI IgG in the control gro up (10.50%) resulted significantly lower than in patients with AMI (37.80%) (p<0.005). There was significant difference between positive anti-β2-GPI test in patients with STEMI and those with NSTEMI (66.7% Vs 36.4%), (p = 0.020). Conclusion: Our findings suggest that anti-beta2-GPI IgG antibodies seemed to behave as independent risk factors for myocardial infarction, which may represent a link b etween autoimmunity and atherosclerosis in patients with acute myocardial infarction. Further studies with bigger patients are needed to explore association of anti-β2-GPI IgG with STEMI and NSTEMI.
Highlights
Cardiovascular Diseases (CVD) remain one of the leading causes of deaths despite several advancements in the medical interventions
Anticardiolipin and anti-beta2-gpI antibodies in patients smoking, according to the criteria of the British with acute coronary heart disease, analyzes their Council for Medical Research; (4) history of heart frequency in patients with acute myocardial infarction and raises the possibility that anti-beta2-gpI antibodies act as independent risk factors for acute myocardial infarction in south of IRAN by the traditional EnzymeLinked Immunosorbent Assay (ELISA) method
We examined the association between positive antiβ2-GPI tests and selected cardiovascular risk factors
Summary
Cardiovascular Diseases (CVD) remain one of the leading causes of deaths despite several advancements in the medical interventions. The frequency of anti-beta2-gpI antibodies, as well as their role in patients with acute myocardial antiphospholipid syndrome, or diseases of the connective tissue. The study protocol was accepted by research ethics committee of Jahrom University of Medical Sciences and informed consents were obtained from all participants before enrollment. The patient or his legal representative provided written informed consent. Anticardiolipin and anti-beta2-gpI antibodies in patients smoking, according to the criteria of the British with acute coronary heart disease, analyzes their Council for Medical Research; (4) history of heart frequency in patients with acute myocardial infarction and raises the possibility that anti-beta2-gpI antibodies act as independent risk factors for acute myocardial infarction in south of IRAN by the traditional EnzymeLinked Immunosorbent Assay (ELISA) method
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