Abstract
Many factors play a role in Acute Myocardial Infarc tion (AMI). One those anti-Phospholipid (aPL) antibodies, that may act in the induction of immuno logical response leading to the development of AMI. Anti-Phosphatidylcholines (PC) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of anti-PC antibody in AMI might shed light on etiologic mechanisms in the pathogenesis of acute coronary syndromes. This study was designed to investigate whether prev alence of anti-PC antibodies, in patients who had AMI and to analyze their relationship with traditio nal cardiovascular risk factors. The prevalence of anti-PC IgG and IgM in a well characterized group o f patients with AMI as a case group and in age and sex matched healthy subjects as control group. Sera from the case and the control groups were tested to evaluate the presence of IgG and IgM isot ypes to anti-PC by ELISA method. The prevalence of anti-PC IgG and also IgM in the case group resul ted significantly higher than in the control group with AMI (p<0.005). Our findings suggest that anti- PC antibodies seemed to play a role in AMI, independent risk factors for AMI, which may represe nt a link between autoimmunity and atherosclerosis in patients with AMI. Further studi es with bigger sample size including patients with AMI and healthy people are needed to explore the ex act role of anti-PC antibodies in AMI.
Highlights
In addition to the Classical Lupus AnticoagulantAntiphospholipid antibodies in addition to repeated miscarriages and pregnancy complications (Jahromi et al, 2010a) are associated with cardiovascular diseases (Jahromi et al, 2013; Shojaie and Jahromi, 2011; Jafarzadeh et al, 2011)
Our findings suggest that anti-PC antibodies seemed to play a role in Acute Myocardial Infarction (AMI), independent risk factors for AMI, which may represent a link between autoimmunity and atherosclerosis in patients with AMI
It should be noted that genetic factors as well as other traditional risk factors such as smoking, hypercholesterolemia, diabetes mellitus and hypertension may contribute to IHD development and these parameters differ among various population
Summary
Antiphospholipid antibodies (aPL) in addition to repeated miscarriages and pregnancy complications (Jahromi et al, 2010a) are associated with cardiovascular diseases (Jahromi et al, 2013; Shojaie and Jahromi, 2011; Jafarzadeh et al, 2011). Their pathogenic (LAC) and Anti-Cardiolipin Antibodies (ACA), other anti-Phospholipid Antibodies (aPL) were shown to target anionic phospholipids and other plasma proteins, including phosphatidylethanolamine, protein C, protein S, ß2-Glycoprotein I (beta2-gpI) and annexin V mechanisms are still matter of investigation. This study was conducted to evaluate the serum levels of Anti-Phosphatidylcholines (PC) antibodies (IgG and IgM) in Iranian patients with AMI and to clarify their association with traditional risk factors of the disease
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