Abstract
Introduction. The increased production of new drugs is parallel with the bacterial adaptation to adverse conditions. There are several factors that have been pointed out as the cause of this, such as: globalization; the abusive use of antibiotics; and the arbitrary prescription of these drugs. Therefore, the objective of the present study was to evaluate antimicrobial usage with antibiotic resistance in 2012 and 2013 at a university hospital in Southern Brazil. Material and Methods. This study was performed at the University Hospital Dr. Miguel Riet Correa Jr. in Rio Grande/RS, Brazil. The data were collected between January 2012 and December 2013, using data from the medical clinic and two intensive care units. Results. Were observed, 385 and 464 cases of bacterial infections, during the years of 2012 and 2013, respectively. Acinetobacter baumannii, Escherichia coli and Klebsiella pneumoniae were the most prevalent species. The total antibiotic consumption in the University Hospital (HU-FURG) in this period was 3.865 units/dose, with 1.995 units/dose in the year 2012 and 1.870 units/dose in the year 2013. Relationships between the rates of main resistant pathogens isolated and the annual consumption of the corresponding antibiotic (carbapenems, cephalosporins, sulfonamides and other β-lactams) were observed; however, they did not show significant positive associations in increased resistance associated with increased consumption. Conclusion. This study reveals the need for the dissemination and feedback of these data to clinicians and decision-makers at the hospital, as it may be crucial to improve policies on prescribing antibiotics and to implement effective infection control.
Highlights
The increased production of new drugs is parallel with the bacterial adaptation to adverse conditions
This study regarding the association between antimicrobial resistance and antibiotic use at a University Hospital Dr Miguel Riet Correa Jr (HU-FURG) discloses three important points
The notable trends in antimicrobial usage demonstrated an increase in the use of aminoglycosides in both prophylactic and therapeutic applications; second, the general use, mainly of the carbapenemics and other βlactams in the hospital have been associated with the increase in or maintenance of the profile “resistant” in the isolates identified in the period of study; third, even with the reduction in the use of some classes, such as the class of "other β-lactams"
Summary
The increased production of new drugs is parallel with the bacterial adaptation to adverse conditions. The objective of the present study was to evaluate antimicrobial usage with antibiotic resistance in 2012 and 2013 at a university hospital in Southern Brazil. This study reveals the need for the dissemination and feedback of these data to clinicians and decision-makers at the hospital, as it may be crucial to improve policies on prescribing antibiotics and to implement effective infection control. The increased production of new drugs is parallel with the bacterial adaptation to adverse conditions, and the resistance is primarily the result of this exposure (Barriere, 2015; Spellberg, Bartlett, & Gilbert, 2013). The fact that distinguishes an antimicrobial from any other therapeutic product is the ability of the first to lose effectiveness over time, requiring the constant replacement of these through the discovery of new drugs (Luepke et al, 2013). Escherichia coli, Staphylococcus aureus, and Streptococcus pneumoniae are the most commonly reported resistant bacteria (WHO, 2018)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
