Abstract
Study design: cross-sectional. Objective: To determine the HPV prevalence and genotypes in women treated at University Hospital in southern Brazil. Methodology: Cervical cells samples from 200 women were collected. HPV was detected by nested polymerase chain reaction and genotypes were determined by sequencing. Variables were analyzed by the Fisher Exact Test and Chi-squared test of Pearson (X²) with a significance level of ≤ 5%. The strength of association was calculated by the prevalence ratio, with their confidence intervals at 95%. Multivariate analysis was calculated by Binary Logistic Regression for variables with P <0.20 Results: HPV DNA was detected in 55 women (27.5%). HPV prevalence was associate with income (P =0.01), early initiation of sexual life (P <0.001), pregnant (P = 0. 002), HIV- 1 infection (P = 0. 001) and koilocytosis presence in cytological test (P =0.006). Were found an association between serological status for HIV-1 and the genotypes HPV–33 (P =0.001) and HPV–68 (P <0.001). Multivariate analysis showed that HPV prevalence was associated with patients who had early initiation of sexual life (P =0.001), was infected by HIV–1 (P = 0.01), was pregnant (P = 0.02), and women with koilocytosis in cytological test (P =0.01). Genotypes were 90.4% higher-risk oncogenic (18 HPV–18, 14 HPV–16, four HPV–53, three HPV–31, two HPV–58, two HPV–59, two HPV–68, one HPV–33 and one HPV–52) and 9.6% low-risk (two HPV–11, two HPV–16 and one HPV–70). Conclusions: This study had the HPV prevalence similar to prevalence described in this region. The high-risk HPV genotypes were the most prevalent, being HPV–18 the main viral type found.
Highlights
Os fatores de risco associados com a infecção pelo HPV descritos na literatura são o início precoce das relações sexuais, o número de parceiros sexuais, uso de contraceptivos orais, a infecção pelo HIV–1, a gestação, o tabagismo, a baixa renda, a baixa escolaridade e a idade.[1,3,4]
Os HPV são classificados em genótipos de baixo risco (HPV–6, HPV– 11, HPV–70), que estão relacionados com as verrugas genitais[2] e os genótipos de alto risco oncogênico (HPV–16, HPV–18, HPV–31, HPV–33 HPV–52, HPV– 53), associados com lesões intraepiteliais e câncer.[2,3]
Reduction in Human Papillomavirus (HPV) Prevalence Among Young Women Following HPV Vaccine Introduction in the United States, National Health and Nutrition Examination Surveys, 2003 – 2010 [Internet]
Summary
Lisiane O Teixeira[1], Valdimara C Vieira[2], Fabiana N Germano[3], Carla V Gonçalves[4], Marcelo A Soares[5], Ana MB Martinez[6]. Objetivo do estudo: Determinar a prevalência e os genótipos do HPV em mulheres atendidas em um Hospital Universitário no Sul do Brasil. O HPV foi detectado pela Reação em Cadeia da Polimerase aninhada e os genótipos por sequenciamento. A prevalência do HPV foi associada a baixa renda (P =0,01), o início sexual precoce (P
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