Intensive care unit patients on mechanical ventilation at a university hospital in southern Brazil: characteristics, mortality, frequency, and mortality risk factors

J Brauner,M Ficanha,L Sehn,A Guntzel,R Cardoso,A Wolmeister,S Vieira,A Milani,M Bozzetti,G Machado,R Sens,L Fialkow

doi:10.1186/cc5323

Abstract

Acute respiratory failure (ARF) is a frequent cause of admission to ICUs and frequently necessitates mechanical ventilation (MV). Knowledge about the frequency and risk factors associated with requirements for MV is crucial to improve outcomes. The objectives of our study were to determine the characteristics, frequency of MV, overall and specific mortality rates and mortality risk factors in patients who required MV in the ICU of a general university hospital in southern Brazil.

Highlights

To clarify the relation between ATP and prostaglandinE2 (PGE2) in the immunologic system, we investigated the acute and chronic effects of PGE2 on activation of purinergic signaling in monocytes by measuring the ATP-induced elevation of intracellularCa2+ ([Ca]i) in fura-2-loaded THP-1 monocytes
IFNγ plays a critical role in host defense by promoting Th1 phenotype and bacterial clearance
Low IFNγ levels are were washed, loaded with fura-2-AM, and transferred into a quartz associated with the Th2 phenotype consistent with critical illness cuvette and placed in the thermostat-regulated sample chamber of anergy [2]

Summary

Introduction

To clarify the relation between ATP and prostaglandinE2 (PGE2) in the immunologic system, we investigated the acute and chronic effects of PGE2 on activation of purinergic signaling in monocytes by measuring the ATP-induced elevation of intracellularCa2+ ([Ca]i) in fura-2-loaded THP-1 monocytes. Several experimental studies suggest that thrombolysis therapy acts directly on thrombi or emboli and enhances microcirculatory reperfusion In this retrospective study we investigated the extent of blood coagulation and fibrin formation via the plasma D-dimer level, an indicator of endogenous fibrinolytic activity, in patients who underwent inhospital and out-of-hospital cardiac arrest from nontraumatic causes. Methods MEDLINE, EMBASE, CINAHL, and the Cochrane Library were searched, and studies were included if they reported on ICU patients > 16 years old who were evaluated for CINMA clinically and electrophysiologically, and they contained sufficient data to quantitatively measure the association between CINMA and clinically relevant exposures and/or outcomes. Our aim was to evaluate the role of the cardiac markers NT-proBNP, Troponin T (TnT) and myoglobin as predictors of inhospital and 6-month all-cause mortality in patients admitted to a general adult ICU with severe sepsis/septic shock. Aging is associated with decreased cardiopulmonary and renal reserve as well as the development of progressive organ failure

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Conclusion