Antibiotic Resistance and Sensitivity Pattern of Pseudomonas aeruginosa Obtained from Clinical Samples

Abstract

This study aimed to determine the antibiotic susceptibility profile of Pseudomonas aeruginosa from fifty different isolates of varied clinical origins. A total of 700 samples of pus, urine, swab, and other samples from various patients were examined. Based on bacterial growth over routine nutrient agar and MacConkey medium, isolates with positive results on both media were chosen. Using the modified disc-diffusion method (Modified-Kirby Baur method), antimicrobial sensitivity of total isolates was operated by following CLSIs guidelines. In the current study, a large number of isolates of P. aeruginosa obtained from different specimens are resistant to Cefixime (82%), followed by Ampicillin (79%) and Augmentin (61%). However, the antibiogram of P. aeruginosa also showed that most of the isolates (86%) were highly sensitive to Amikacin. The second maximum sensitivity of P. aeruginosa was seen towards Tazocin (80%), followed by Tecarcilline (79%). P. aeruginosa offers a high risk of antibiotic resistance to a wide range of antibiotics; hence it is necessary to avoid the use of antibiotics to reduce antibiotic resistance. Also, researchers should search for the discovery of certain novel antibiotics that may provide impressive inhibition toward Pseudomonas aeruginosa.