Antibacterial study of silver doped zinc oxide nanoparticles against Staphylococcus aureus and Bacillus subtilis

Abstract

ObjectivesThe present study has been undertaken to synthesize silver doped zinc oxide nanoparticles, with pharmaceutical importance. The synthesized particles have been evaluated to study the effect of silver doping on grain size and further on antibacterial activities against the microorganisms Bacillus subtilis and Staphylococcus aureus. MethodsSilver doped zinc oxide nanoparticles were prepared by the solution route spin-coating process, using zinc acetate (Zn(CH3COO)2.2H2O) and silver nitrate (AgNO3) as host and dopant precursors respectively. The antibacterial activity of the silver doped zinc oxide were studied against S. auerus and B. subtilis via using agar well diffusion method. Results & discussion: The structure of the powder samples was analyzed by X-ray diffraction (XRD). The effect of silver doping on grain size and further on antibacterial activity against the microorganisms B. subtilis and S. auerus is discussed. ConclusionIt was clear from X-ray investigations that its structure is wurtzite type and that an increase in Ag-doping resulted in decrease in the grain size of the ZnO nanoparticles. Antimicrobial study against the microorganisms B. subtilis and S. auerus shows that in case of S. auerus the MIC varies with increase in Ag content but in case of B. subtilis the MIC remained constant for all concentration of Ag.