Abstract
Ocular drug-delivery is one of the most challenging areas owing to nature of ocular tissues. Various nanoformulations have been designed and investigated for drug-delivery to achieve high drug bioavailability.The major focus ofpreparations available in market isto utilizenanomaterial as drug-carrier, withless focus on developing functional-nanomaterials, which is a key knowledge gap in the field. To address this, we developed a nanoparticulate system from bioactive-polymers having intrinsic antimicrobial and mucoadhesivenessloaded with ciprofloxacin (cipro) to treat bacterial ocular infections. Cipro-loaded lecithin/chitosan nanoparticles were prepared and characterized for their physiochemical properties. They exhibited good drug loading efficiency and showed sustained drug-release for 72 h, with slow release for first 4 h followed by a burst release in phosphate buffered salineand simulated tear fluid. Cipro-loaded nanoparticles were assessed for their antibacterial potential against Staphylococcus aureus(96%) and Pseudomonas aeruginosa (72%) using optical density, disc-diffusion method, live-dead assay, and demonstrated promising antibacterial properties. The drug-loaded nanoparticles showed good cytocompatibility (~90%) towards murine fibroblasts and rabbit corneal cells. Being amphiphilic in nature, the nanoparticles exhibited mucoadhesiveness,haemocompatibility (<4%) and, thus, proving to be a promising candidate for treating ocular infections. This approach ensures efficient drug delivery and synergic/additive therapeutic effects.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call