Antibacterial and anticoagulation properties of carboxylated graphene oxide–lanthanum complexes

Abstract

The anticoagulation and antibacterial properties of biomaterials are crucial for biomedical applications, especially for blood-contacting materials. Herein, we prepare carboxylated graphene oxide complexes with lanthanum(III). The complexes were characterized by FT-IR, TG, TEM, AFM, and Raman. Results show that the lanthanum(III) has been coordinated on the graphene oxide sheet. The antibacterial property of the complexes is determined by the kinetics of bacterial growth and bacterial inhibition zone. The results show that GeneO–La complexes have a good inhibitory effect under the concentration of 1.0 mg mL−1. The anticoagulation property of complexes is evaluated by a hemolysis test and recalcification time test. The plasma recalcification time gradually decreases with the increasing concentration of complexes. The hemolysis rate is less than 5% at lower concentrations of complexes as consistent the Hormesis effect of rare earth elements. GeneO–La complexes have both antibacterial and anticoagulation properties, which indicates potential as blood-contact materials.