Facile Fabrication of Mussel‐Inspired Multifunctional Polymeric Membranes with Remarkable Anticoagulant, Antifouling, and Antibacterial Properties

Abstract

AbstractHerein, a facile one‐step surface modification technique of coating functional biopolymer conjugated mussel‐inspired catechol (CA) onto substrate is applied to confer polyethersulfone (PES) membranes with remarkable blood compatibility, antifouling property, and antibacterial property, respectively. CA conjugated poly(2‐acrylamido‐2‐methylpropanesulfonic acid) (PAMPS), poly(sulfobetaine methacrylate) (PSBMA), and poly(methacryloxyethyltrimethyl ammonium chloride) are synthesized via free radical polymerization in the presence of CA, and simultaneously coated onto PES membrane surface. The surface chemical compositions, surface zeta‐potential convince the successful preparation of the modified PES membranes. PAMPS‐coated membrane exhibits excellent blood compatibility, especially anticoagulation property; PSBMA‐coated membrane displays excellent antifouling property and blood compatibility; meanwhile, PDMC‐coated membrane shows robust bactericidal property. In general, this work demonstrates that the mussel‐inspired surface modification protocol provides a facile and versitile method to confer the substrate with excellent blood compatibility, antifouling property, and antibacterial property, respectively, which has great potential for multibiomedical applications, such as blood purification, hemodialysis, and organ implantation.