Abstract
ABSTRACT Background: This study aimed to investigate the antianemic activity of plant-extracted succinic acid and hexamethylcyclotrisiloxane in Wistar rats with alloxan-induced diabetes. Methods: The experiment was conducted at the Enugu State University of Science and Technology, Faculty of Pharmaceutical Sciences, Department of Pharmacology, Agbani, Enugu State. A total of 42 healthy male and female Wistar rats weighing approximately 100–150 g were randomly divided into seven groups, each comprising six rats. Group A (normal control) was only fed with water and food. Group B (the negative control group) was induced with diabetes using alloxan and left untreated. Group C (the positive control group) was induced and treated with metformin. Group D (test Group I) was treated with a combination of succinic acid and hexamethylcyclotrisiloxane in a 50:50 ratio at 100 mg/kg body weight. Group E (test Group 2) was treated with succinic acid only at 100 mg/kg body weight. Group F (test Group 3) was treated with hexamethylcyclotrisiloxane at 100 mg/kg body weight. Group G (test Group 4) received a combination of succinic acid and hexamethylcyclotrisiloxane in a 50:50 ratio at 200 mg/kg body weight. Several in vitro laboratory investigations were conducted to determine the activity of these phytocompounds in erythrocytes. Results: After 4 weeks of treatment, Group G, which received the 50:50 combination of succinic acid and hexamethylcyclotrisiloxane at 200 mg/kg body weight, demonstrated significantly greater recovery from anemia (P <0.05). This finding suggests a possible synergistic effect in a dose- dependent manner. Conclusion: A 50:50 combination of succinic acid and hexamethylcyclotrisiloxane at a dose of 200 mg/kg body weight exhibits synergistic effects and may serve as a potential therapeutic option for preventing and treating anemia caused by chemically induced type 2 diabetes.
Published Version
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