Abstract
Aloe vera L (A. barbadensis) is commonly used medicinal and cosmetic plant. In the present investigations the anti necrotic and anticlastogenic activity of Aloe vera extract was studied using Skin Papilloma, Melanoma Bone marrow micronucleus and chromosomal assays in Swiss albino and C57 Bl mice. It has been observed that topical application of Aloe vera extract on the skin tumour induced by DMBA (7.12 Dimethyl Benz (a) nthracene) and croton oil have significantly reduced the tumour size, weight and histological changes as compared to control group. Antinecrotic activity was also observed in skin melanoma tumour induced by subcutaneous administration of B6 F10 cell lines in C57 Bl mice. It reduced the tumour volume and increases the significant survival of animals as compared to control group. In anticlastogenic activity, Aloe vera extract have significantly prevented chromosomal aberrations and micronucleus formations in dose dependent manner. Results suggest the antinecrotic and anticlastogenic potential of Aloe vera extract in the above test systems.
Highlights
In recent years, there have been considerable efforts to find naturally occurring substances that can inhibit, reverse, or retard mutagenesis
These studies suggest a possible benefit of using aloe gel and aloe extract in cancer chemoprevention
The Aloe vera extract was prepared from the gel collected from leaves as described in our earlier paper (Agrawal et al, 2013)
Summary
There have been considerable efforts to find naturally occurring substances that can inhibit, reverse, or retard mutagenesis. (A. barbadensis) is used for several ailments Some recent studies have demonstrated the direct inhibitory effects of aloe extract and aloe gel on both tumor initiation and promotion. Aloe gel caused an induction of glutathione-S-transferase and inhibition of tumor promoting effects of phorbol myristic acetate [8]. These studies suggest a possible benefit of using aloe gel and aloe extract in cancer chemoprevention. [13] Antinecrotic and anticlastogenic activity gel and extract have not been well reported previously in these studies preventive effects of Aloe vera extract has been studied using skin Papilloma model, micronucleus and chromosomal tests The alcoholic extract of Aloe vera has dose dependently inhibited gastric acid secretion . [10] Aloe emodin of Aloe vera have significantly inhibited MCC cells growth and possess specific toxicity to neuroectodermal cells . [11] Acemann a carbohydrate from Aloe vera has shown anti immune and anti tumoral activities . [12] The extract exhibited the best for radical scavenging activity . [13] Antinecrotic and anticlastogenic activity gel and extract have not been well reported previously in these studies preventive effects of Aloe vera extract has been studied using skin Papilloma model, micronucleus and chromosomal tests
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