Abstract
Aloe vera L (A. barbadensis) is commonly used medicinal and cosmetic plant. In the present investigations the anti necrotic and anticlastogenic activity of Aloe vera extract was studied using Skin Papilloma, Melanoma Bone marrow micronucleus and chromosomal assays in Swiss albino and C57 Bl mice. It has been observed that topical application of Aloe vera extract on the skin tumour induced by DMBA (7.12 Dimethyl Benz (a) nthracene) and croton oil have significantly reduced the tumour size, weight and histological changes as compared to control group. Antinecrotic activity was also observed in skin melanoma tumour induced by subcutaneous administration of B6 F10 cell lines in C57 Bl mice. It reduced the tumour volume and increases the significant survival of animals as compared to control group. In anticlastogenic activity, Aloe vera extract have significantly prevented chromosomal aberrations and micronucleus formations in dose dependent manner. Results suggest the antinecrotic and anticlastogenic potential of Aloe vera extract in the above test systems.
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