Abstract
Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine ( 1), and ten known natural products, laurotetanine ( 2), liriodenine ( 3), boldine ( 4), secoboldine ( 5), isoboldine ( 6), asimilobine ( 7), oreobeiline ( 8), 6-epioreobeiline ( 9), β-amyrone ( 10), and ( S)-3-methoxynordomesticine ( 11). Chemical studies on the bark of B. kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid, N-dimethylphyllocryptine ( 12). Structures of compounds 1– 12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE), anti-α-glucosidase, anti-leishmanial and anti-fungal activities. Compounds 1– 12 exhibited strong to moderate bioactivities in aforementioned bioassays.
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