Abstract
Phytochemical studies on the methanolic extract of Drypetes gossweileri afforded N-β- d-glucopyranosyl- p-hydroxyphenylacetamide ( 1), p-hydroxyphenylacetic acid ( 2), p-hydroxyphenyl-acetonitrile ( 3), p-hydroxyacetophenone ( 4), 3,4,5-trimethoxyphenol ( 5), dolichandroside A ( 6), and β-amyrone ( 7). Compounds 1– 7 were identified with the aid of extensive NMR and MS spectroscopic studies. Compound 1 was a new natural product and was isolated for the first time from plant containing N-glucose moiety incorporated in its structure. Compounds 1– 7 exhibited moderate to the weak source anti-α-glucosidase inhibitory activity. Compound 7 exhibited moderate anti-acetylcholinesterase (AChE) activity while the rest of the isolates were weakly active in this bioassay. Compounds 1– 7 also showed moderate anti-fungal activity.
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