Abstract
Plasma concentrations of human atrial natriuretic peptide (hANP) were measured before and after hemodialysis (HD) in 19 patients undergoing chronic HD. We examined plasma hANP concentrations before HD in 36 patients, then re-examined the same patients 1 year later to assess annual changes. Plasma concentrations of hANP had decreased significantly from 262±38pg/ml (mean±SE) to 164±19pg/ml after HD (p<0.001). There was a significant correlation (p<0.05) between changes in plasma hANP concentrations and decreased body weight during HD. Plasma hANP concentrations correlated significantly (p<0.01) with mean blood pressure. Plasma hANP concentrations in the second year increased significantly as compared with those of the first year (p<0.05). There was a significant correlation (p<0.001) between the plasma hANP concentration in the first year and that in the second year. These results suggest that plasma hANP concentration may serve as a control index of body weight and hypertension, and may be a prognostic indicator in patients receiving chronic HD.
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