Abstract
IntroductionThere is considerable homology amongTP53/TP63/TP73 genes. The last of these is located at 1p36.33; a chromosome region frequently deleted in a wide variety of tumours of the nervous system. This suggests that these genes could be involved in the development of oligodendrogliomas.Material and methodsWe performed a DNA mutation study using PCR/SSCP methods and sequencing of theTP53/TP63/TP73 genes in a series of 41 patients with oligodendrogliomas.ResultsWe found one mutation (518 T→C; Val173Ala) in theTP53 gene and none in theTP63 andTP73 genes. The other nucleotide changes identified corresponded to polymorphisms.ConclusionsThese data suggest that mutations of theTP53 gene family do not appear to play a significant role in the pathology of oligodendrogliomas.
Published Version
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