Abstract
The use of an iodinated contrast agent for ablation of renal tissue was investigated in 14 mongrel dogs. An occlusion balloon catheter was percutaneously placed in a renal artery, and 24–36 ml of diatrizoate meglumine and sodium (Renografin-76) was infused over 3–10 sec. Injection was repeated until a uniform persistent stain was achieved. Six dogs were restained in 4–6 wks when follow-up arteriography demonstrated residual renal cortex. Creatinine and renal vein renin values, aortograms, and renal arteriograms were obtained before and 1, 4, and 14 wks after staining. All dogs were sacrificed for gross and histologic studies. In all the stained kidneys, renins dropped initially a minimum of 71%, then rose up to 90% (3.45/3.85μg/ml/min) of but did not exceed the opposite kidney. The average decrease in renal length was 49%. Arteriograms in each animal before sacrifice revealed marked reduction of the renal artery with extensive pruning and tortuosity of intrarenal branches. In three dogs, the renal artery was completely occluded. None had discernible nephrographic stain or visualization of the collecting system on aortography. Grossly, the stained kidneys were small with smooth capsules, surrounded by inflammatory reaction. There was complete or nearly complete destruction of the glomeruli with extensive coagulation necrosis. In selected cases this method provides a potential alternative to surgery or other angiographic means of renal ablation. Supported by MSR&E grant #60–79-80.
Published Version
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