Abstract
To evaluate if gender implies any difference in ischemia detection both by perfusion and function abnormalities using gatedSPECT myocardial scintigraphy in patients with typical angina, normal coronary angiography, and endothelial dysfunction, 31 women (Group I) and 20 men (Group II) were studied. Each underwent technetium-99m methoxy-isobutyl-isonitrile myocardial scintigraphy, brachial artery endothelial function measured by ultrasonography and lipidogram. Five female and eight male patients showed a reversible perfusion defect with post-stress left ventricular ejection fraction (LVEF) reduction greater than 5%, associated with endothelial dysfunction in three women and four men. There was no significant difference neither in presence of endothelial dysfunction, nor in LVEF post-stress minus LVEF at rest (ΔLVEF): -2.71% in women vs. -2.41% in men. In patients with typical angina, normal coronary angiography and abnormal SPECT myocardial scintigraphy (both by perfusion and poststress left ventricular ejection fraction reduction), gender does not account for differences in the detection of ischemia.
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