Abstract
Axoplasmic fluid properties for neuronal excitation have been investigated with respect to temperature. Density, the mass fraction of ions and rate of addition of ions are the parameters considered for characterizing axoplasmic fluid properties. The behavior of these parameters has been analyzed with respect to the changes in temperature ranging from -5 degree Celsius to 35 degree Celsius. The temperature has been defined using Q10of3 coefficient as done in the Hodgkin-Huxley model. The trend of these parameters at different temperatures has been depicted along the axonal length represented through x-axis of the graphs. The conduction velocities of the above said parameters have also been recorded at different temperatures. The range [-5,35] degree Celsius has been increased by 20 degrees, 10 degree on the lower side and 10 degree on the upper side of the range [-5,25] degree Celsius and it is found that temperature dependency using Q10of3 coefficient for said parameters is valid only in the temperature ranging from 5 degree Celsius to 25 degree Celsius as it is for membrane voltage in the Hodgkin-Huxley model. These findings strongly support the obtained results and also suggest obtaining the temperature coefficient value which is applicable for a wider range of temperatures impacting neuronal excitation.
Highlights
Information transmission is one of the important features that differentiate neurons from other cells.Different types of neurons perform different types of functions both in animals and in the human body
We have taken into consideration the negative range to analyze how action potential propagation velocity reduced at a negative temperature and to check whether this effect can be utilized for anesthesia for inhibiting the action potential propagation
It is clear from the observations given under Results and Discussion section, that temperature impacts action potential and the other parameters defining axoplasmic fluid properties namely: density, mass fraction of ions and rate of addition of ions
Summary
Information transmission is one of the important features that differentiate neurons from other cells. The model proposed in [2] for neuronal excitation based on axoplasmic fluid properties has investigated the impact of temperature on action potential propagation velocity and axoplasmic fluid viscosity. Their model incorporates other parameters namely: density, the mass fraction of ions, the rate of addition of ions and temperature dependent longitudinal diffusivity. Considering the fact that temperature is a very crucial parameter for neuronal excitation, it becomes important to analyze the above-said parameters with respect to changes in temperature, since the mass fraction and the rate of addition of ions impact ionic diffusion. Ionic transport that takes place due to opening and closing of ionic channels is represented through the following equations: (6), (7) and(8) respectively for sodium, potassium and chlorine ions and written as follows:
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