Analyze correlation detecting microembolic signals on transcranial Doppler in patients with large artery atherosclerotic cerebral infarction and ischemic stroke recurrence

Abstract

Objective Analyze the prevalence of MES in the large artery atherosclerosis, and the influence factors of the MES rate and the relationship between MES and ischemic stroke recurrence. Methods A total of 267 patients with LAA cerebral infarction were selected from October 2012 to February 2014 in Yuncheng Central Hospital, all use MES monitoring, and regular follow-up observation. Analysis of the influencing factors of MES and the proportion and risk of recurrent stroke in patients with positive and negative groups. Results MES positive rate was 16.5% (44/267) in patients with type LAA cerebral infarction. MES positive group of high density lipoprotein (HDL) and platelet count ( 0.94±0.21) mmol/L, (275.2±99.5)×109/L, MES negative group corresponding index for (1.06±0.24) mmol/L, (218.5±64.7)×109/L, this difference was statistically significant (P<0.05). The presence of MES was more frequent in patients with large severe stenosis artery (29.7%) than those with mild-moderate stenosis artery (6.0%), this difference was statistically significant (P<0.001). The rate of recurrence was 18.2% (8/44) vs 2.7% (6/223) between the MES positive and negative groups. The presence of MES predicted ischemic events recurrence (Log-rank=10.609, P=0.001) by Kaplan-Meier analysis. This remained significant (RR=8.332, 95%CI:1.945 - 35.695, P=0.003 ) after Cox regression was used to control for influencing factors. Conclusion MES can be a significant independent predictor of ischemic events recurrence in patients with large artery atherosclerotic cerebral infarction.The presence of MES associates with the number of platelet and the degree of large artery severe stenosis. Key words: Cerebral apoplexy; Microembolic signal; Atherosclerosis; Platelet count