Abstract
Carvedilol and ivabradine is a drug combination used to treat cardiovascular diseases like hypertension, chronic stable angina pectoris and, chronic heart failure. Both are different in their mode of action. Carvedilol prevents exercise-induced tachycardia via inhibition of beta-adrenoreceptor carvedilol, which also acts on alpha-1 adrenergic receptors and reduces blood pressure. In case of a higher dose also shows antioxidant and calcium channel blocking activity. Ivabradine is a heart rate-reducing drug that works by blocking cardiac pacemaker currents (If) selectively and specifically. The major goal of this review paper is to emphasize the characteristics of carvedilol and ivabradine, such as their pharmacological profiles, mechanisms of action, pharmacokinetic and pharmacodynamic studies, and previously described analytical methodologies for carvedilol and ivabradine determination. Various methods such as UV spectroscopy High-performance liquid chromatography (HPLC), Reverse phase -High performance liquid chromatography (RP-HPLC), Ultra-performance liquid chromatography (UPLC), Mass Spectrometry (MS), High-performance thin layer chromatography (HPTLC). is the most accurate easy method for estimation.
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