Abstract
This article explores the search for new analytical reactions and the determination of optimal conditions that can serve as a basis for the quantitative analysis of penicillins. Two unified procedures have been developed for the quantitative determination of ticarcillin in pure substance and pharmaceutical formulations using kinetic-spectrophotometric and redox titration methods with potassium hydrogenperoxomonosulphate. A chemical transformation scheme of ticarcillin with potassium hydrogenperoxomonosulphate has been proposed. The kinetics of the coupled reactions of S-oxidation and perhydrolysis of ticarcillin in an alkaline medium were studied by measuring the increase in light absorbance of the reaction product at 295 nm. The appearance of a new absorption band enables the development of a novel procedure for the quantitative determination of ticarcillin. The reaction rate was monitored spectroscopically and displayed in real time. A differential variation of the tangent method was used to process the kinetic data.
Published Version
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