Analysis of therapeutic effect of sodium hyaluronate intra-articular injection combined with oral Yanghe decoction in the treatment of knee osteoarthritis

Abstract

Objective To investigate the curative effect of sodium hyaluronate intraperitoneal injection combined with oral Yanghe decoction in the treatment of knee osteoarthritis. Methods 80 patients with knee osteoarthritis were randomly divided into two groups, 40 cases in each group.The control group was given intra-articular injection of sodium hyaluronate, and the study group was treated with Yanghe decoction in addition.The TCM symptom score, knee joint index, overall treatment effect and quality of life were compared between the two groups. Results The total score of TCM symptoms after treatment in the study group was (7.08±1.18)points, which was significantly lower than (10.42±2.01)points in the control group(t=9.063, P<0.01). The VAS score and WOMAC score after treatment in the study group were (1.48±0.59)points, (19.10±3.08)points, respectively, which were significantly lower than (3.70±1.12)points and (23.40±3.56)points in the control group(t=11.091, 5.777, all P<0.01). The HSS score after treatment in the study group was (83.04±10.49)points, which was significantly higher than (71.81±9.67)points in the control group(t=4.978, P<0.01). The physiological function, physical function, physical pain, mental health and energy scores after 6 months treatment in the study group were significantly higher than those in the control group (t=5.190, 8.535, 4.569, 3.266, 6.694, all P<0.01). The effective rate and total effective rate of the study group were 72.5% and 95.0%, respectively, which were significantly higher than those of the control group(50.0%, 77.5%), the differences were statistically significant(χ2=4.266, 5.165, all P<0.05). Conclusion Sodium hyaluronate injection combined with oral Yanghe decoction is effective in the treatment of knee osteoarthritis. Key words: Osteoarthritis, knee; Joint capsule; Sodium hyaluronate; Medicine, Chinese traditional