Analysis of the relationship between serum HBV-DNA quantitative detection level and liver function markers and hepatitis B markers in patients with chronic hepatitis B virus

Abstract

Objective To investigate the relationship between serum HBV-DNA quantitative detection level and liver function markers and hepatitis B markers in patients with chronic hepatitis B virus. Methods The clinical data of 80 patients with chronic hepatitis B virus infection were retrospectively analyzed, and the HBV-DNA load, the serum hepatitis B markers and liver function indicators of the patients were detected and recorded.Another 80 cases received normal physical examination were selected as the control group.The serum markers were detected in both two groups. Results Of 80 patients with chronic hepatitis B virus infection, the positive rate of HBV-DNA was 45.0% (36/80) and the detection rate of HBeAg was 30.0% (24/80). The positive rate of HBV-DNA was positively correlated with HBeAg positive rate(χ2=12.46, P=0.00). The levels of alanine aminotransferase (ALT), α-L-fucosidase (AFU), aspartate aminotransferase (AST) and plasma prothrombin time (PT) in HBV-DNA positive patients were significantly higher than those in HBV-DNA negative group(F=42.693, 18.752, 32.692, 48.225, all P=0.000); and with the increase of the amount of virus, the level of the patients' index continued to increase. Conclusion For patients with chronic hepatitis B, the HBV-DNA level and the viral replication should be detected, and the liver function should be evaluated to observe the liver damage timely, thus to provide reference for clinical effective intervention. Key words: Hepatitis B, chronic; DNA; Liver function tests