Analysis of the effect of pregnancy complicated with acute pancreatitis on maternal and infant outcomes

Abstract

Objective To explore the effect of pregnancy with acute pancreatitis on maternal and infant outcomes, thus to provide reference for the development of clinical intervention programs. Methods From January 2012 to January 2018, 62 pregnant patients with acute pancreatitis in the Maternal and Child Health Hospital of Jiaxing were selected as study objects.All of them were singletons.The patients were grouped according to the cause of acute pancreatitis and the severity of the disease.The pregnancy outcomes and neonatal conditions were analyzed. Results Of 62 patients with acute pancreatitis, 40 cases (64.52%) had full-term delivery, 20 cases (32.26%) had premature delivery, and 2 cases(3.22%) had intrauterine fetal death.The newborns included in the study were 60 cases.There were no statistically significant differences in the proportion of premature infants between different morbidity factors, neonatal birth weight and neonatal disease composition (the premature infants: F=0.691, P=0.352; birth weight: F=1.042, P=0.382; biliary erythremia: F=1.382, P=0.521; respiratory distress syndrome: F=0.496, P=0.584; hypoglycemia: F=3.102, P=0.165; infectious disease: F=0.895, P=0.124; intracranial hemorrhage: F=0.004, P=0.932). The difference of termination pregnancy rate was statistically significant (biliary 57.69%, hyperlipidemia 82.14%, other 25.00%) (F=12.541, P=0.000), and the rate of the lipemia group was the highest (82.14%). The proportion of premature infants with moderate pregnancy and acute pancreatitis was the highest (75.0%), and the birth weight was the lowest (F=8.142, 4.581, P=0.000, 0.001). The proportion of termination of pregnancy among different degrees of disease had no statistically significant difference (mild 12.19%, moderate 75.0%, and severe 69.23%) (F=1.251, P=0.4125). The intracranial hemorrhage (0.00%), neonatal respiratory distress syndrome (2.44%) and infectious disease rate (4.88%) were the lowest in mild pregnancy with acute pancreatitis (F=8.641, 7.362, 6.982, P=0.000, 0.000, 0.000). Conclusion Pregnancy with acute pancreatitis can cause adverse pregnancy outcomes and affect the health of newborns.As the patients' condition worsens, the adverse outcome will be more serious. Key words: Pregnancy outcome; Pancreatitis; Infant, premature; Pregnancy complications; Respiratory distress syndrome, newborn