Abstract
Pulmonary tuberculosis (PTB) is one of the most common infectious diseases worldwide, with extremely high morbidity and mortality. An in-depth understanding of the molecular pathogenesis of PTB is crucial for finding novel diagnostic and therapeutic approaches in the future. In this study, we identified 52 differentially expressed genes (DEGs), which consisted of 422 nodes and 2853 edges, from the GSE34608 dataset in the Gene Expression Omnibus (GEO) database. These DEGs were composed of 422 nodes and 2,853 edges. Functional enrichment analysis revealed that CARD11 and MYO1G are closely related to T-cell activation. Upon further clinical case analysis, we found that the expression of CARD11 and MYO1G in the peripheral blood of patients with PTB were lower than those of healthy individuals, demonstrating excellent diagnostic value for both PTB diagnosis and prognosis of recurrence. Thus, CARD11 and MYO1G are promising indicators for assessing PTB in the future.
Published Version
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