Analysis of screening results for congenital hypothyroidism in preterm infants

Abstract

Objective To discuss the effect of neonatal congenital hypothyroidism(CH)screening in preterm infants. Methods The result of 208 713 cases neonatal congenital hypothyroidism screening in Guangzhou neonatal screening center were analyzed,including 11589 cases preterm infant and 197 124 cases of full term.The difference of screening positive rate and incidence between preterm infants and full term infants group were compared and the efficiency of preterm infants congenital hypothyroidism screening were estimated. Results A total of 208 713 newborns were screened and the screening positive rate was 1.39%.123 cases were confirmed positive for CH and the incidence rate was 1/1 697.124 cases were screening positive in preterm infants and the screening positive rate was 1.06%.14 cases were confirmed positive for CH and the incidence rate was 1/828 in preterm infants group.2 771 cases were screening positive in full term infants and the screening positive rate was 1.41%.109 cases were confirmed positive for CH and the incidence rate was 1/1 809 in full term group.The screening positive rate was lower and the incidence rate of preterm infants group(χ2=4.89,P<0.05)was higher than that of the full term infants group(χ2=8.26,P<0.05). Conclusion The incidence rate of congenital hypothyroidism is higher in preterm infants.Neonatal screening is an effective measure for early diagnosis of preterm infants congenital hypothyroidism. Key words: Preterm infants; Hypothyroidism,congenital; Neonatal screening